Tim Tebow and Matt Leinart won Heismans.
Steve Young, Ken Stabler, Mark Brunell and Boomer Esiason went on to successful NFL careers.
MORE: QBs who switched positions | SN Top 25: Best/worst cases
Michael Vick and Pat White changed the way the quarterback position was played.
And all of these QBs have one thing in common: they're left-handed.
To celebrate National Left Handers Day, we're looking at 20 of the most interesting lefty quarterbacks to play college football.
Mark Brunell, Washington
Brunell was part of a run for Washington in the early 1990s and was MVP of the 1991 Rose Bowl. He started in two Rose Bowls for the Huskies.
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Armanti Edwards, Appalachian State
Edwards was one of the game's most dynamic players, regardless of division. He led the Mountaineers to three consecutive Division I-AA national titles. In four seasons, he threw for 10,392 yards with 74 passing TDs while rushing for 4,361 yards and 65 more scores.
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Boomer Esiason, Maryland
Esiason totaled 6,259 yards and 42 TDs and went on to a successful career in the NFL. He earned NFL MVP honors in 1988.
MORE: Top 15 programs since 2000
David Greene, Georgia
Greene finished his Bulldog career as the all-time leader in wins (42) and SEC all-time leader in passing yards (11,528). Both those records later were broken. He threw 72 TD passes during his career in Athens, Ga., and completed 59.0 percent of his throws.
Josh Heupel, Oklahoma
Heupel helped usher in the Bob Stoops era at Oklahoma. He led the Sooners to the national championship in 2000 and finished second in the Heisman Trophy voting.
Brock Huard, Washington
He followed his brother, Damon, as the Huskies quarterback. He threw for 5,742 yards in three seasons with 51 touchdown passes from 1996 to 1998.
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Stefan Lefors, Louisville
After seeing little of the field his first two seasons, Lefors threw for 3,145 and 2,596 yards as a junior and senior with the Cardinals. He also ran for 738 yards those final two seasons and scored six times on the ground.
Matt Leinart, USC
In three seasons in L.A., Leinart threw for 10,693 yards, 99 TDs, just 23 picks, won the Heisman Trophy in 2004 and the Trojans were 37-2 with a BCS championship in 2004.
Jared Lorenzen, Kentucky
The “Hefty Lefty” tossed for 10,354 yard and 78 TDs at Kentucky from 2000-03 and continues to be a hit on social media to this day.
Todd Marinovich, USC
One of the most-decorated high school players of all time, Marinovich played two seasons at USC before the Los Angeles Raiders selected him in the first round of the 1991 NFL Draft.
Cade McNown, UCLA
McNown put up huge numbers for the Bruins. He totaled 10,708 career passing yards with 68 TD passes and another 16 on the ground. He threw for 3,116 and 3,470 in his final two seasons, accumulating 49 touchdown passes.
MORE: SN's 10 greatest all-time Bruins
Scott Mitchell, Utah
Mitchell broke out at Utah with 4,322 yards and 29 TDs in 1988. He passed for 31 TDs the following season and played 11 years in the NFL.
Kellen Moore, Boise State
Moore is the face of Boise State’s run in the BCS era. He won 50 games in four seasons and threw for 142 TDs from 2008-11.
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Mike Shula, Alabama
As the team's starter in 1985 and 1986, Shula threw for 3,495 yards and 29 TDs as the Crimson Tide compiled a 19-5-1 record. Shula later would become head coach at Alabama and was 26-23 although 16 wins later were vacated.
Chris Simms, Texas
The son of Phil Simms, Chris Simms threw for 7,097 yards during his Longhorn career, including a 3,207-yard performance as a senior with 26 TD passes as Texas finished 11-2.
Ken Stabler, Alabama
Stabler led Alabama to an 11-0 record in 1966, which included a 34-7 win against Nebraska in the Sugar Bowl. He went on to become a Super Bowl champion with the Oakland Raiders. “The Snake” passed away on July 8, 2015.
MORE: SN's 10 greatest Alabama players
Tim Tebow, Florida
Tebow tossed 88 TDs and ran for 57 more scores as a two-time national champion and Heisman Trophy winner at Florida. Don’t forget about “The Speech.”
MORE: 10 memorable college games for Tebow
Michael Vick, Virginia Tech
Vick remains one of the most-exciting college football quarterbacks of all time. He led Virginia Tech 2000 Sugar Bowl with an endless selection of highlight-reel plays.
MORE: SN's 10 greatest Hokies
Pat White, West Virginia
One of the game's best dual-threat quarterbacks, White completed 64.8 percent of his career passes for 6,049 yards and 56 TDs. He ran for 4,480 yards and 47 scores as well.
Steve Young, BYU
Young, another link to the long line of quarterbacks at BYU, passed for 33 TDs and completed 71.3 percent of his passes. That foreshadowed a Hall of Fame career in the NFL.